 Fasteners for affixing sheet -like materials to bone or tissue
专利摘要:
A fastener for attaching a sheet-like implant to tissue or bone may be provided with a first arm having a proximal end and a distal end, a second arm having a proximal end and a distal end, and a bridge extending therebetween. Each of the first and second arms include a trunk portion defining at least a portion thereof, the trunk portion having a lateral extent larger than a lateral extent of the bridge or non-trunk portion of the arm adjacent thereto and can be mounted eccentrically to the bridge or non-trunk portion of the arm adjacent thereto such that the staple includes a first change in lateral stiffness disposed proximate the bridge or non-trunk portion of the arm abutment with the trunk. Fastener delivery devices and methods are also disclosed. 公开号:AU2012369140A1 申请号:U2012369140 申请日:2012-12-17 公开日:2014-07-03 发明作者:Charles L. Euteneuer；Duane Frion；Rebecca Mccarville 申请人:Rotation Medical Inc； IPC主号:A61B17-064
专利说明:
WO 2013/119321 PCT/US2012/070150 FASTENERS FOR AFFIXING SHEET-LIKE MATERIALS TO BONE OR TISSUE CROSS REFERENCE TO RELATED APPLICATIONS 5 [00011 This application claims priority to U.S. Provisional Application No. 61/577,626 filed on December 19, 2011, the disclosure of which is incorporated by reference herein. The present disclosure is related to the following commonly assigned co-pending applications, the disclosures of which are incorporated herein by reference: U.S. Provisional Application No. 61/577,621 filed on December 19, 2011, Attorney Docket No. 10322-711.100 entitled, 10 "APPARATUS AND METHOD FOR FORMING PILOT HOLES IN BONE AND DELIVERING FASTENERS THEREIN FOR RETAINING AN IMPLANT" ; U.S. Provisional Application No. 61/577,632 filed on December 19, 2011, Attorney Docket No. 10322-713.100 entitled, "FASTENERS AND FASTENER DELIVERY DEVICES FOR AFFIXING SHEET LIKE MATERIALS TO BONE OR TISSUE" and U.S. Provisional Application No. 61/577,635 15 filed on December 19, 2011, Attorney Docket No. 10322-714.100 entitled, "FASTENERS AND FASTENER DELIVERY DEVICES FOR AFFIXING SHEET-LIKE MATERIALS TO BONE OR TISSUE." INCORPORATION BY REFERENCE [00021 All publications and patent applications mentioned in this specification are herein 20 incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. FIELD [00031 The present invention relates generally to orthopedic medicine and surgery. More 25 particularly, the present invention relates to methods and apparatus for delivery and fixation of sheet-like materials, such as for treating tendons or like tissue of articulating joints such as tendons in the rotator cuff of the shoulder. BACKGROUND 30 [0004] The glenohumeral joint of the shoulder is found where the head of the humerus mates with a shallow depression in the scapula. This shallow depression is known as the glenoid fossa. Six muscles extend between the humerus and scapula and actuate the glenohumeral joint. These six muscles include the deltoid, the teres major, and the four rotator cuff muscles. The rotator cuff muscles are a complex of muscles. The muscles of the rotator cuff include the 35 supraspinatus, the infraspinatus, the subscapularis, and the teres minor. The centering and - 1- WO 2013/119321 PCT/US2012/070150 stabilizing roles played by the rotator cuff muscles are critical to the proper function of the shoulder. The rotator cuff muscles provide a wide variety of moments to rotate the humerus and to oppose unwanted components of the deltoid and pectoral muscle forces. [0005] The muscles of the rotator cuff arise from the scapula. The distal tendons of the 5 rotator cuff muscles splay out and interdigitate to form a common continuous insertion on the humerus. The supraspinatus muscle arises from the supraspinatus fossa of the posterior scapula, passes beneath the acromion and the acromioclavicular joint, and attaches to the superior aspect of the greater tuberosity. The mechanics of the rotator cuff muscles are complex. The rotator cuff muscles rotate the humerus with respect to the scapula, compress the humeral head into the 10 glenoid fossa providing a critical stabilizing mechanism to the shoulder (known as concavity compression), and provide muscular balance. The supraspinatus and deltoid muscles are equally responsible for producing torque about the shoulder joint in the functional planes of motion. [0006] The rotator cuff muscles are critical elements of this shoulder muscle balance equation. The human shoulder has no fixed axis. In a specified position, activation of a muscle 15 creates a unique set of rotational moments. For example, the anterior deltoid can exert moments in forward elevation, internal rotation, and cross-body movement. If forward elevation is to occur without rotation, the cross-body and internal rotation moments of this muscle must be neutralized by other muscles, such as the posterior deltoid and infraspinatus. The timing and magnitude of these balancing muscle effects must be precisely coordinated to avoid unwanted 20 directions of humeral motion. Thus the simplified view of muscles as isolated motors, or as members of force couples must give way to an understanding that all shoulder muscles function together in a precisely coordinated way--opposing muscles canceling out undesired elements leaving only the net torque necessary to produce the desired action. Injury to any of these soft tissues can greatly inhibit ranges and types of motion of the arm. 25 [0007] With its complexity, range of motion and extensive use, a common soft tissue injury is damage to the rotator cuff or rotator cuff tendons. Damage to the rotator cuff is a potentially serious medical condition that may occur during hyperextension, from an acute traumatic tear or from overuse of the joint. With its critical role in abduction, rotational strength and torque production, the most common injury associated with the rotator cuff region is a strain or tear 30 involving the supraspinatus tendon. A tear at the insertion site of the tendon with the humerus, may result in the detachment of the tendon from the bone. This detachment may be partial or full, depending upon the severity of the injury or damage. Additionally, the strain or tear can occur within the tendon itself. Injuries to the supraspinatus tendon and current modalities for treatment are defined by the type and degree of tear. The first type of tear is a full thickness tear, 35 which as the term indicates is a tear that extends through the thickness of the supraspinatus -2- WO 2013/119321 PCT/US2012/070150 tendon regardless of whether it is completely torn laterally. The second type of tear is a partial thickness tear which is further classified based on how much of the thickness is torn, whether it is greater or less than about 50% of the thickness. [0008] The accepted treatment for a full thickness tear or a partial thickness tear greater than 5 50% includes reconnecting the torn tendon via sutures. For the partial thickness tears greater than 50%, the tear is completed to a full thickness tear by cutting the tendon prior to reconnection. In contrast to the treatment of a full thickness tear or a partial thickness tear of greater than 50%, the current standard treatment for a partial thickness tear less than 50% usually involves physical cessation from use of the tendon, i.e., rest. Specific exercises can also be 10 prescribed to strengthen and loosen the shoulder area. In many instances, the shoulder does not heal and the partial thickness tear can be the source of chro-nic pain and stiffness. Further, the pain and stiffness may cause restricted use of the limb which tends to result in further degeneration or atrophy in the shoulder. Surgical intervention may be required for a partial thickness tear of less than 50%, however, current treatment interventions do not include repair of 15 the tendon, and rather the surgical procedure is directed to arthroscopic removal of bone to relieve points of impingement or create a larger tunnel between the tendon and bone that is believed to be causing tendon damage. As part of the treatment, degenerated tendon may also be removed using a debridement procedure in which tendon material is ablated. Again, the tendon partial thickness tear is not repaired. Several authors have reported satisfactory early post 20 operative results from these procedures, but over time recurrent symptoms have been noted. In the event of recurrent symptoms, many times a patient will "live with the pain". This may result in less use of the arm and shoulder which causes further degeneration of the tendon and may lead to more extensive damage. A tendon repair would then need to be done in a later procedure if the prescribed treatment for the partial tear was unsuccessful in relieving pain and stiffness or 25 over time the tear propagated through injury or degeneration to a full thickness tear or a partial thickness tear greater than 50% with attendant pain and debilitation. A subsequent later procedure would include the more drastic procedure of completing the tear to full thickness and suturing the ends of the tendon back together. This procedure requires extensive rehabilitation, has relatively high failure rates and subjects the patient who first presented and was treated with 30 a partial thickness tear less than 50% to a second surgical procedure. [0009] As described above, adequate treatments do not currently exist for repairing a partial thickness tear of less than 50% in the supraspinatus tendon. Current procedures attempt to alleviate impingement or make room for movement of the tendon to prevent further damage and relieve discomfort but do not repair or strengthen the tendon. Use of the still damaged tendon 35 can lead to further damage or injury. Prior damage may result in degeneration that requires a -3- WO 2013/119321 PCT/US2012/070150 second more drastic procedure to repair the tendon. Further, if the prior procedure was only partially successful in relieving pain and discomfort, a response may be to use the shoulder less which leads to degeneration and increased likelihood of further injury along with the need for more drastic surgery. Further, it would be beneficial to be able to treat partial thickness tears 5 greater than 50% without cutting the untorn portion of the tendon to complete the tear before suturing back together. There is a large need for surgical techniques and systems to treat partial thickness tears and prevent future tendon damage by strengthening or repairing the native tendon having the partial thickness tear. 10 SUMMARY OF THE DISCLOSURE [000101 The present disclosure is generally directed to a fastener or staple that can be used to attach an implant to bone or other tissue. The staple or fastener can be included in a kit or system that also can include a staple delivery device and a pilot hole forming trocar assembly. The trocar assembly is used to create pilot holes and retain instrument position within those pilot 15 holes for staple insertion. The staple delivery device can carry the staple into the pilot holes and release the staple in engagement with bone to retain the implant in position. [000111 The staple for insertion and retention in bone can include a bridge portion having arms extending from proximate each end thereof, at least a portion of each arm including tissue retention members, each tissue retention member having at least two barbed projections 20 extending laterally therefrom. Each arm can have a cross sectional area of reduced strength proximate each projection relative to other portions of the tissue retention member such that a portion of the tissue retention member flexes laterally proximate each projection in response to a pullout force applied to the bridge. The tissue retention members can include a trunk of greater cross sectional area than a non-trunk portion of the arms. 25 [00012] The fastener or staple can also include, in alternative embodiments, a first arm having a proximal end and a distal end, a second arm having a proximal end and a distal end, and a bridge connecting the first arm and second arm, wherein each of the first and second arms include a trunk portion extending over at least a portion of the length thereof. Each trunk can have a lateral extent larger than a lateral extent of the bridge or non-trunk arm portion adjacent 30 thereto such that the staple includes a first change in lateral stiffness disposed proximate the bridge or non-trunk arm portion abutment with the first trunk and a second change in lateral stiffness disposed proximate the bridge or non-trunk arm portion abutment with the second trunk. The lateral extent of each trunk in at least one direction can be at least about three times the lateral extent of at least a portion of the bridge or non-trunk portion of the arm. -4- WO 2013/119321 PCT/US2012/070150 [00013] Each trunk can further include a first projection and a second projection, the first projection including a first proximal surface extending away from the trunk in a first direction, the first direction being such that the first proximal surface will engage the tissue or bone when the trunk is inserted therein so that a first moment is applied to the trunk in response to a pullout 5 force on the bridge. Likewise, the second projection can include a second proximal surface extending away from the trunk in a second direction, the second direction being such that the second proximal surface will engage the tissue or bone when the trunk is inserted therein so that a second moment is applied to the trunk in response to a pullout force on the bridge. Each of the trunks can further include a localized area of weakness proximate the second projection thereon. 10 For example, a second area of reduced strength can include a slit in the cross section of the tissue retention member or trunk adjacent at least one of the projections therefrom. Further, reduced strength can be created where the trunk meets the non-trunk portion of the arm adjacent thereto or the bridge. [000141 In some embodiments, the change in lateral stiffness and the localized area of 15 weakness allow flexing of each arm portion in response to the first and second moment, respectively. [00015] The projections can be arranged to extend in first and second directions to achieve increased pullout strength. The first direction can extend proximally and laterally away from each trunk while the second direction can extend proximally and laterally away from each trunk 20 and a lateral component of the second direction is generally opposite a lateral component of the first direction. The forces on the projections create moments about the more flexible portions of the staple where the direction of the first moment is generally opposite the direction of the second moment on each arm. [00016] In some embodiments, the fastener first trunk and the second trunk each define a 25 cavity, each cavity being spaced laterally from the respective non-trunk portion or bridge adjacent thereto. Each cavity defined by the first and the second trunk is sized to receive a first stake and a second stake, respectively, of a fastener delivery device. Each cavity defined by the first and the second trunk can extend from the proximal end to the distal end of the trunk. 30 BRIEF DESCRIPTION OF THE DRAWINGS [00017] Figure 1 is a perspective view illustrating an exemplary tissue fastener or staple in accordance with the present disclosure; [00018] Figure 2 is a an alternative perspective view of the tissue fastener or staple of Figure 1 illustrating other features in accordance with the present disclosure; -5- WO 2013/119321 PCT/US2012/070150 [00019] Figure 3 is a top plan view of the tissue fastener or staple of Figure 1 illustrating the laterally extending legs having lumens for receiving the stakes of a delivery device for positioning the staple in desired tissue; [00020] Figure 4 is a front plan view of the tissue fastener or staple of Figure 1 illustrating in 5 phantom flexing of the barbs and legs of the staple in response to grasping of tissue in one embodiment of the disclosure; [00021] Figure 5 is a stylized anterior view of a shoulder including a humerus and a scapula; [00022] Figure 6 is a stylized of a shoulder depicting the head of the humerus shown mating with the glenoid fossa of the scapula at a glenohumeral joint and a sheet-like material is affixed 10 to the tendon; [00023] Figure 7 is a stylized perspective view showing a portion of the body of a human patient divided into quadrants by planes for descriptive purposes herein; [00024] Figure 8 is a stylized perspective view illustrating an exemplary procedure for arthroscopic treatment of a shoulder of a patient in accordance with one embodiment of the 15 disclosure; [00025] Figure 9 is a stylized perspective view of a shoulder including a supraspinatus having a distal tendon with a sheet-like material affixed thereto; [00026] Figure 10A is a simplified perspective view of a tissue fastener or staple delivery device in accordance with the present disclosure; 20 [00027] Figure 1 OB is a simplified perspective view of a trocar assembly, including a trocar disposed within a guide sheath assembly for creating pilot holes and retaining the sheath within the formed pilot holes for delivery of a tissue fastener or staple by a device such as that depicted in Figure 1OA; [00028] Figure 1 lA is a perspective view of the sheath assembly of Figure 1 OB with the trocar 25 removed; [00029] Figure 11 B is a perspective view of the trocar of Figure lOB as removed from the sheath assembly; [00030] Figure 11 C is a perspective view of one pilot hole position retention member which is positioned in a distal portion of the sheath assembly in one embodiment of the present 30 disclosure; [00031] Figure 12 is a perspective view depicting the sheath and staple pusher assemblies of a staple delivery device in one embodiment of the disclosure; [00032] Figure 13 is a simplified exploded view of the tissue fastener or staple delivery device of Figure 1 OA depicting additional features thereof; 35 [00033] Figure 14 depicts further features of the staple pusher assembly of Figure 13; -6- WO 2013/119321 PCT/US2012/070150 [00034] Figures 15A and 15B illustrate the features of the distal portion of the staple pusher assembly of Figure 13 with a staple mounted thereon in accordance with one embodiment of the disclosure; [00035] Figure 16A and 16B further illustrate the staple pusher assembly in one embodiment 5 of the disclosure; [00036] Figure 17 is a more detailed perspective view of the distal portion of the staple pusher assembly illustrating stakes that mate with the staple in one embodiment of the disclosure; [00037] Figure 18A is simplified perspective view of a shoulder having an implant affixed to the tendon and depicting the first step in a method of delivering fasteners to affix the implant to 10 bone of the humeral head in accordance with one method of the disclosure; [000381 Figure 18B is a simplified plan view of the distal portion of the trocar assembly as position to create pilot holes for affixing the implant to bone in a further step of a method of the disclosure; [00039] Figure 18C depicts the trocar assembly of Figure 18B as inserted into the bone to 15 form pilot holes in accordance with a method of the disclosure; [00040] Figure 18D depicts the trocar assembly with the trocar portion removed and the remaining sheath assembly retaining its position in the pilot holes formed; [00041] Figure 18E depicts insertion of a fastener or staple into the formed pilots holes through the sheath assembly in accordance with a method of the disclosure; and, 20 [00042] Figure 18F illustrates a fastener or staple as inserted in accordance with a method of the disclosure. DETAILED DESCRIPTION [000431 The following detailed description should be read with reference to the drawings in 25 which similar elements in different drawings are numbered the same. The drawings, which are not necessarily to scale, depict illustrative embodiments and are not intended to limit the scope of the invention. [000441 Figure 1 is a perspective view illustrating an exemplary staple 100 in accordance with the present detailed description. With reference to Figure 1, it will be appreciated that staple 100 30 may assume various orientations without deviating from the spirit and scope of this detailed description. Although the various parts of this exemplary embodiment are depicted in relative proportion to other parts of the staple 100, other configurations in size and orientation of the various parts are possible. A number of reference directions are illustrated using arrows in Figure 1 to assist in understanding the details of the staple 100. The illustrated directions include: a 35 proximal direction P, a distal direction D, a first laterally outward direction LOA, a second -7- WO 2013/119321 PCT/US2012/070150 laterally outward direction LOB, a first laterally inward direction LIA, and a second laterally inward direction LIB. [00045] Staple 100 comprises a first arm 102A, a second arm 102B, and a bridge 104 extending from, abutting or adjacent to the proximal end of first arm 102A to the proximal end 5 of second arm 102B. The first arm 102A includes a first trunk 106A extending for at a least a portion of the length of the first arm 102A. As depicted in Figure 1, a proximal portion of the first arm 102A abuts the proximal end of the first trunk 106A. The first arm 102A, in this embodiment includes the trunk portion 106A and a non-trunk portion 105A. The length of first trunk 106A relative to the overall length of the first arm 102A can vary in different 10 embodiments. The first trunk 106A can extend for the entire length of the first arm 102A such that the bridge abuts with or is adjacent to the trunk 106A. Similarly, the second arm 102B includes a second trunk 106B extending for at least a portion of the length of the second arm 102B. A proximal portion of the second arm 102B abuts the proximal end of the second trunk 106B. The second arm 102B, in this embodiment includes the trunk portion 106B and a non 15 trunk portion 105B. The length of second trunk 106B relative to the overall length of the second arm 102B can vary in different embodiments. The second trunk 106B can extend for the entire length of the second arm 102B such that the bridge abuts with or is adjacent to the trunk 106B. In Figure 1, first trunk 106A and second trunk 106B are shown extending distally from a proximal portion of first arm 102A and second arm 102B, respectively. 20 [00046] In the embodiment of Figure 1, first trunk 106A has a lateral extent, or cross sectional area, that is larger than a lateral extent of the non-trunk portion 105A of first arm 102A and bridge 104. The staple 100 includes a first change in lateral stiffness 108A disposed where the distal end of non-trunk portion 105A of first arm 102A abuts first trunk 106A. As depicted, the change in stiffness is abrupt, but can be gradual in alternative embodiments. In an embodiment 25 where the first trunk 106A extends for the full length of the first arm 102A, the change in stiffness occurs where the first trunk 106A abuts the bridge 104. With reference to Figure 1, it will be appreciated that first trunk 106A is mounted eccentrically to first arm 102A and second trunk 106B is mounted eccentrically to second arm 102B. As with first trunk 106A, second trunk 106B has a lateral extent, or cross sectional area that is larger than a lateral extent of 30 second arm 102B or bridge 104. The staple 100 includes a second change in lateral stiffness 108B where the distal end of second arm 102B abuts second trunk 106A in the embodiment of Figure 1. If the second trunk 106B extends for the entire length of second arm 102B, the change in stiffness occurs at the abutment with the bridge 104. [00047] Each of the first trunk 106A and second trunk 106B can include at least a first 35 projection 122A, 122C and a second projection 122B, 122D, the first projection 122A, 122C on -8- WO 2013/119321 PCT/US2012/070150 each trunk 106A, 106B includes a first proximal surface 124A, 124C extending away from the trunk in a first direction, the first direction being such that the first proximal surface 124A, 124C will engage the tissue or bone after the trunk is inserted therein and a pullout force is applied to the bridge 104. This force creates a first moment centered on the area of reduced lateral extent 5 adjacent the trunk, tending to rotate the trunk thereabout, further providing a greater holding force in response to the pullout force as the trunk presses against the tissue or bone. The second projection 122B, 122D includes a second proximal surface 124B, 124D extending away from the trunk in a second direction, different from the first direction, the second direction being such that the second proximal surfaces 124B, 124D will engage the tissue or bone after the trunk is 10 inserted therein and a pullout force is applied to the bridge 104. A slit or area of reduced cross section in the trunk adjacent the second projections provide an area of weakness so that a second moment is applied to the trunk in response to a pullout force on the bridge 104. This moment causes rotation of the trunk about the area of weakness and increases the holding force with increased pullout force. 15 [00048] As specifically illustrated in the embodiment of staple or fastener 100 in Figure 1, first trunk 106A includes a first projection 122A disposed at an outer side of trunk 106A and a second projection 122B disposed at an inner side of the trunk. First projection 122A includes a first proximal surface 124A extending away from first trunk 106A in a first direction. With reference to Figure 1, it will be appreciated that the first direction has an outward lateral 20 component and a proximal component so that first proximal surface 124A extends outwardly and proximally away from first trunk 106A. The first direction is selected such that first proximal surface 124A will engage tissue or bone proximate the outer side of first trunk 106A after being inserted therein so that a first moment is applied to the trunk in response to a pullout force on bridge 104. The moment centers on the arm portion of lesser cross section adjacent the first 25 projection. [00049] In the embodiment of Figure 1, first trunk 106A includes a first localized area of weakness 120A disposed proximate second projection 122B. Second projection 122B includes a second proximal surface 124B extending away from first trunk 106A in a second direction. The second direction is selected such that second proximal surface 124A will engage tissue or bone 30 proximate the inner side of first trunk 106A when inserted therein so that a second moment is applied to the trunk in response to a pullout force on bridge 104. The moment centers around the area of weakness 120A. The second moment has a direction that is generally opposite a direction of the first moment. It will be appreciated that the second direction has an inward lateral component and a proximal component so that second proximal surface 124B extends 35 inwardly and proximally away from first trunk 106A. -9- WO 2013/119321 PCT/US2012/070150 [00050] Second trunk 106B includes a third projection 122C disposed at an outer side of second trunk 106B and a fourth projection 122D disposed at an inner side of the trunk. In the embodiment of Figure 1, third projection 122C includes a third proximal surface 124C extending away from second trunk 106B in a third direction. With reference to Figure 1, it will be 5 appreciated that the third direction has an outward lateral component and a proximal component so that third proximal surface 124C extends outwardly and proximally away from second trunk 106B. The third direction is selected such that third proximal surface 124C will engage tissue or bone proximate the outer side of second trunk 106B when inserted therein so that a third moment is applied to the trunk in response to a pullout force on bridge 104. 10 [000511 In the embodiment of Figure 1, second trunk 106B includes a second localized area of weakness 120B disposed proximate fourth projection 122D. Fourth projection 122D includes a fourth proximal surface 124D extending away from second trunk 106B in a fourth direction. In the embodiment of Figure 1, the fourth direction is selected such that second proximal surface 124A will engage tissue or bone proximate the inner side of second trunk 106B when inserted 15 therein so that a fourth moment is applied to the trunk in response to a pullout force on bridge 104. The fourth moment has a direction that is generally opposite a direction of the third moment. It will be appreciated that the fourth direction has an inward lateral component and a proximal component so that fourth proximal surface 124D extends inwardly and proximally away from second trunk 106B. 20 [000521 As depicted in Figure 1, the staple 100 includes proximal projections that extend away from or outward from the bridge 104, while the distal projections extend inward or toward the center of the bridge 104. This creates generally opposing forces in response to tension on the bridge which, in combination with areas of weakness or reduced lateral extent, substantially increases the holding force of the staple in bone as the different portions of the trunks tend to 25 rotate in opposite directions and apply force to an opposing wall in the hole in bone in which the staple is positioned. It is however, understood that other configurations of the projections are possible. In some embodiments, at least two projections are included and they extend in different directions to cause different force responses as tension is applied to the bridge. It is believed this provides adequate holding force in bone, which can include differing thicknesses of 30 hard and soft tissue along with porous areas. [000531 In some useful embodiments, each projection of staple 100 may be clefted to form a plurality of points for greater retention in tissue. In the exemplary embodiment of Figure 1, first projection 122A of first trunk 106A defines a first notch 126A that divides first projection 122A into a first sub-projection and a second sub-projection. Second projection 122B of second trunk 35 106B defines a second notch 126B. In the exemplary embodiment of Figure 1, second notch -10- WO 2013/119321 PCT/US2012/070150 126B divides second projection 122B into a first sub-projection and a second sub-projection. Third projection 122C of second trunk 106B defines a third notch 126C that divides third projection 122C into a first sub-projection and a second sub-projection. Fourth projection 122D of second trunk 106B defines a fourth notch 126D that divides fourth projection 122D into 5 a first sub-projection and a second sub-projection. [00054] With continued reference to Figure 1 and further reference to Figures 2 and 3, first trunk 106A defines a first cavity 128A and second trunk 106B defines a second cavity 128B. In the exemplary embodiment of Figures 1, 2 and 3, first cavity 128A extends into first trunk 106A and second cavity 128B extends into second trunk 106B. The cavity is sized to cooperate with a 10 staple delivery device for holding and inserting the staple into tissue or bone, as later described in detail herein. In summary, the staple delivery device includes longitudinally extending stakes that fit within the cavities 128A, 128B to hold the staple 100 and push it into position in the tissue as the stake abuts a portion of its respective trunk. In some embodiments the cavity may extend through a portion of the length of each trunk, as best depicted in Figure 2 which indicates 15 the distal end of the staple 100 is closed. Alternatively, first cavity 128A and second cavity 128B may extend through the entire length of each trunk 106A, 106B or other portions of staple 100 in some embodiments. As illustrated by the top view of the staple 100 in Figure 3, first cavity 128A and second cavity 128B each have a generally rectangular or square cross-sectional shape to cooperate with a similarly shaped cross section on a staple delivery device. However, 20 that first cavity 128A and second cavity 128B may have various cross-sectional shapes to cooperate with alternative staple delivery device designs without deviating from the spirit and scope of the present detailed description. [00055] Figure 4 is an alternative perspective view of the embodiment in Figure 1 illustrating an exemplary staple 100 in accordance with the present detailed description. In particular, Figure 25 4 illustrates in phantom the flexing and bending of the trunks 106A and 106B after implant in response to tension applied to the bridge, as by tissue or an implant affixed at an implant site. Staple 100 comprises a first arm 102A, a second arm 102B, and a bridge 104 extending from the proximal end of first arm 102A to the proximal end of second arm 102B. The distal end of first arm non-trunk portion 105A abuts the proximal end of first trunk 106A. Similarly, the distal end 30 of second arm non-trunk portion 105B abuts the proximal end of a second trunk 106B. In Figure 4, first trunk 106A and second trunk 106B are shown extending distally from first arm 102A and second arm 102B, respectively. [000561 In the embodiment of Figure 4, first trunk 106A has a lateral extent that is larger than the lateral extent of the non-trunk portion 105A of first arm 102A. This combination creates a 35 relatively abrupt change in lateral stiffness 108A disposed where the distal end of the non-trunk - 11 - WO 2013/119321 PCT/US2012/070150 portion 108A of first arm 102A abuts first trunk 106A. With reference to Figure 4, first trunk 106A is mounted eccentrically to first arm 102A and second trunk 106B is mounted eccentrically to second arm 102B, however, other mountings or abutments can be used, such as a non-trunk portion having walls that surround the cavity and include a lumen therethrough to access the 5 cavity with a staple delivery stake. A change in lateral stiffness would still be accomplished where the lateral extend changed. Further, a change in lateral stiffness could be accomplished by using a different material for the non-trunk portion relative to the trunk portion. Second trunk 106B in combination with the non-trunk portion 105B of second arm 102B provides the same change in lateral stiffness 108B. 10 [00057] As earlier described the configuration of the four projections 122A, 122B, 122C and 122D, contact the tissue or bone and provide a holding force upon implantation. Each projection is positioned to provide a force moment in a desired direction to the trunk in response to the pullout force on the bridge 104. [00058] In the embodiment of Figure 4, first trunk 106A and second trunk 106B include first 15 and second localized areas of weakness 120A, 120B disposed proximate second projections 122B, 122D. This area of weakness is formed by a slit formed proximal of the projection. However, the area of weakness could be formed by other means, such as a change in material, pinching or perforations. [00059] The combination of projections, areas of weakness and changes in lateral extent 20 provide desired flexing, bending and rotating of the trunk in response to pull out forces once implanted in a bone, such as in a pilot hole formed in the bone. Together these components act as tissue retention members. An exemplary deflected shape is shown with dashed lines in Figure 4. Staple 100 may be urged to assume the deflected shape shown in Figure 4, for example, by applying a pullout force on the bridge 104 of the staple 100. Alternatively, distally directed 25 forces can be applied on staple 100 using, for example, the staple delivery system shown later and described herein. In some applications, the staple delivery tool may be used to urge first projection 122A and third projection 122C into orientations which lock staple 100 into a target tissue. For example, first projection 122A and third projection 122C may be rotated so that these projections engage the target tissue. When this is the case, tension extending through bridge 104 30 of staple 100 may keep first projection 122A and third projection 122C in the rotated position. Also when this is the case, the projections may inhibit staple pullout. Further, rotation of any projection causes a rotational force and within limits defined by the hole in the bone some rotation to an adjacent portion of the trunk which contacts or engages the wall of the hole in the bone. Increased pullout force results in increasing holding force with this design. -12- WO 2013/119321 PCT/US2012/070150 [00060] Next referring to Figure 5, an exemplary use or application of the staples of the present disclosure is described. Figure 5 is a stylized anterior view of a patient 20. For purposes of illustration, a shoulder 22 of patient 20 is shown in cross-section in Figure 5. Shoulder 22 includes a humerus 14 and a scapula 12. In Figure 5, a head 24 of humerus 14 can be seen 5 mating with a glenoid fossa of scapula 12 at a glenohumeral joint. With reference to Figure 5, it will be appreciated that the glenoid fossa comprises a shallow depression in scapula 12. The movement of humerus 14 relative to scapula 12 is controlled by a number of muscles including: the deltoid, the supraspinatus, the infraspinatus, the subscapularis, and the teres minor. For purposes of illustration, only the supraspinatus 26 is shown in Figure 5. 10 [00061] With reference to Figure 5, a distal tendon 28 of the supraspinatus 26 meets humerus 14 at an insertion point. Scapula 12 of shoulder 22 includes an acromium 32. In Figure 5, a subacromial bursa 34 is shown extending between acromium 32 of scapula 12 and head 24 of humerus 14. Subacromial bursa 34 is shown overlaying supraspinatus 26 as well as supraspinatus tendon 28 and a portion of humerus 14. Subacromial bursa 34 is one of the 15 hundreds of bursae found the human body. Each bursa comprises a fluid filled sac. The presence of these bursae in the body reduces friction between bodily tissues. [00062] The exemplary staples or fasteners described herein may be used to affix tendon repair implants to various target tissues. The shoulder depicted in Figure 5 is one example where a tendon repair implant may be affixed to one or more bones associated with an articulating joint, 20 such as the glenohumeral joint. Additionally, the tendon repair implant may be affixed to one or more tendons to be treated. The tendons to be treated may be torn, partially torn, have internal micro-tears, be untorn, and/or be thinned due to age, injury or overuse. Applicants believe that the methods and apparatus of the present application and related devices may provide very beneficial therapeutic effect on a patient experiencing joint pain believed to be caused by partial 25 thickness tears and/or internal microtears. By applying a tendon-repair implant early before a full tear or other injury develops, the implant may cause the tendon to thicken and/or at least partially repair itself, thereby avoiding more extensive joint damage, pain, and the need for more extensive joint repair surgery. [00063] Figure 6 is a stylized anterior view of a shoulder 22 including a humerus 14 and a 30 scapula 12. In Figure 6, a head 24 of humerus 14 is shown mating with a glenoid fossa of scapula 12 at a glenohumeral joint. A supraspinatus 26 is also shown in Figure 6. This muscle, along with others, controls the movement of humerus 14 relative to scapula 12. A distal tendon 28 of supraspinatus 26 meets humerus 14 at an insertion point 30. [00064] As depicted in Figure 6, distal tendon 28 includes a first damaged portion 36. A 35 number of loose tendon fibers 40 in first damaged portion 36 are visible in Figure 6. First - 13 - WO 2013/119321 PCT/US2012/070150 damaged portion 36 includes a first tear 42 extending partially through distal tendon 28. First tear 42 may therefore be referred to as a partial thickness tear. With reference to Figure 6, first tear 42 begins on the side of distal tendon 28 facing the subacromial bursa (shown in the previous Figure) and ends midway through distal tendon 28. Accordingly, first tear 42 may be 5 referred to as a bursal side tear. [00065] With reference to Figure 6, distal tendon 28 includes a second damaged portion 38 located near insertion point 30. As illustrated, second damaged portion 38 of distal tendon 28 has become frayed and a number of loose tendon fibers 40 are visible. Second damaged portion 38 of distal tendon 28 includes second tear 44. Second tear 44 begins on the side of distal tendon 10 28 facing the center of the humeral head 24. Accordingly, second damaged portion 38 may be referred to as an articular side tear. [00066] Figure 6 illustrates a sheet-like implant 50 has been placed over the bursal side of distal tendon 28. The sheet-like implant 50 is affixed to distal tendon 28 by a plurality of tendon staples 51. Sheet-like implant 50 is affixed to humerus 14 by a plurality of bone staples 100 in 15 accordance with designs of staples disclosed herein. Sheet-like implant 50 extends over insertion point 30, first tear 42 and second tear 44. Some useful methods in accordance with this detailed description may include placing a tendon repair implant on the bursal side of a tendon regardless of whether the tears being treated are on the bursal side, articular side or within the tendon. In some cases the exact location and nature of the tears being treated may be unknown. A tendon 20 repair implant may be applied to the bursal side of a tendon to treat shoulder pain that is most likely caused by one or more partial thickness tears in the tendon. [000671 Figure 7 is a stylized perspective view showing a portion of the body 82 of a human patient 20. Body 82 includes a shoulder 22. In the exemplary embodiment of Figure 7, a plurality of cannulas are positioned to access a treatment site within shoulder 22. In some cases, 25 shoulder 22 may be inflated by pumping a continuous flow of saline through shoulder 22 to create a cavity proximate the treatment site. The cannulas shown in Figure 7 include a first cannula 80A, a second cannula 80B and a third cannula 80C. [00068] In Figure 7, a sagital plane SP and a frontal plane FP are shown intersecting body 82. Sagital plane SP and frontal plane FP intersect one another at a medial axis MA of body 82. 30 With reference to Figure 7, sagital plane SP bisects body 82 into a right side 84 and a left side 86. Also with reference to Figure 7, frontal plane FP divides body 82 into an anterior portion 92 and a posterior portion 88. Sagital plane SP and a frontal plane FP are generally perpendicular to one another. These planes and portions are used to describe the procedures used in exemplary embodiments. -14- WO 2013/119321 PCT/US2012/070150 [000691 First cannula 80A is accessing a treatment site within shoulder 22 using a lateral approach in which first cannula 80A pierces the outer surface of right side 84 of body 82. The term lateral approach could also be used to describe situations in which an instrument pierces the outer surface of left side 86 of body 82. Second cannula 80B is accessing a treatment site within 5 shoulder 22 using a posterior approach in which second cannula 80B pierces the outer surface of posterior portion 88 of body 82. Third cannula 80C is accessing a treatment site within shoulder 22 using an anterior approach in which third cannula 80C pierces the outer surface of anterior portion 92 of body 82. [00070] Figure 8 is a stylized perspective view illustrating an exemplary procedure for 10 treating a shoulder 22 of a patient 20. The procedure illustrated in Figure 8 may include, for example, fixing tendon repair implants to one or more tendons of shoulder 22. The tendons treated may be torn, partially torn, have internal micro-tears, be untorn, and/or be thinned due to age, injury or overuse. [00071] Shoulder 22 of Figure 8 has been inflated to create a cavity therein. A fluid supply 52 15 is pumping a continuous flow of saline into the cavity. This flow of saline exits the cavity via a fluid drain 54. A camera 56 provides images from inside the cavity. The images provided by camera 56 may be viewed on a display 58. [000721 Camera 56 may be used to visually inspect the tendons of shoulder 22 for damage. A tendon repair implant in accordance with this disclosure may be affixed to a bursal surface of the 20 tendon regardless of whether there are visible signs of tendon damage. Applicants believe that the methods and apparatus of the present application and related devices may provide very beneficial therapeutic effect on a patient experiencing joint pain believed to be caused by internal microtears, but having no clear signs of tendon tears. By applying a tendon repair implant early before a full tear or other injury develops, the implant may cause the tendon to thicken and/or at 25 least partially repair itself, thereby avoiding more extensive joint damage, pain, and the need for more extensive joint repair surgery. [00073] An implant delivery system 60 can be seen extending from shoulder 22 in Figure 8. Implant delivery system 60 is extending through a first cannula 80A. In certain embodiments, first cannula 80A can access a treatment site within shoulder 22 using a lateral approach in which 30 first cannula 80A pierces the outer surface of a right side of the patient's body. In some cases a physician may choose not to use a cannula in conjunction with implant delivery system 60. When that is the case, the implant delivery system may be advanced through tissue. Implant delivery system 60 comprises a sheath that is affixed to a handle. The sheath defines a lumen and a distal opening fluidly communicating with the lumen. In the embodiment of Figure 8, the - 15 - WO 2013/119321 PCT/US2012/070150 distal opening of the sheath has been placed in fluid communication with the cavity created in shoulder 22. [00074] A tendon repair implant is at least partially disposed in the lumen defined by the sheath of implant delivery system 60. Implant delivery system 60 can be used to place the 5 tendon repair implant inside shoulder 22. In some embodiments, the tendon repair implant is folded into a compact configuration when inside the lumen of the sheath. When this is the case, implant delivery system 60 may be used to unfold the tendon repair implant into an expanded shape. Additionally, implant delivery system 60 can be used to hold the tendon repair implant against the tendon. 10 [00075] The tendon repair implant may be affixed to the tendon while it is held against the tendon by implant delivery system 60. Various attachment elements may be used to fix the tendon-repair implant to the tendon. Examples of attachment elements that may be suitable in some applications include sutures, tissue anchors, bone anchors, and staples. In the exemplary embodiment of Figure 8, the shaft of a fixation tool 70 is shown extending into shoulder 22. In 15 one exemplary embodiment, fixation tool 70 is capable of fixing the tendon repair implant to the tendon and bone with one or more staples of the present disclosure while the tendon repair implant may held against the tendon by implant delivery system 60. [00076] Figure 9 is a stylized perspective view of a shoulder 22 including a supraspinatus 26 having a distal tendon 28. With reference to Figure 9, a tendon repair implant 50 has been 20 affixed to a surface of distal tendon 28. Tendon repair implant 50 may comprise, for example, various sheet-like structures without deviating from the spirit and scope of the present detailed description. In some useful embodiments, the sheet-like structure may comprise a plurality of fibers. The fibers may be interlinked with one another. When this is the case, the sheet-like structure may comprise a plurality of apertures comprising the interstitial spaces between fibers. 25 Various processes may be used to interlink the fibers with one another. Examples of processes that may be suitable in some applications including weaving, knitting, and braiding. In some embodiments, the sheet-like structure may comprise a laminate including multiple layers of film with each layer of film defining a plurality of micro-machined or formed holes. The sheet-like structure of the tendon repair implant may also comprise a reconstituted collagen material having 30 a porous structure. Additionally, the sheet-like structure of the tendon repair implant may also comprise a plurality of electro-spun nanofiber filaments forming a composite sheet. Additionally, the sheet-like structure may comprise a synthetic sponge material that defines a plurality of pores. The sheet-like structure may also comprise a reticulated foam material. Reticulated foam materials that may be suitable in some applications are available from 35 Biomerix Corporation of Fremont, California which identifies these materials using the -16- WO 2013/119321 PCT/US2012/070150 trademark BIOMATERIAL TM. The sheet-like structure may be circular, oval, oblong, square, rectangular, or other shape configured to suit the target anatomy. [00077] Various attachment elements may be used to fix tendon repair implant 50 to distal tendon 28 without deviating from the spirit and scope of this detailed description. Examples of 5 attachment elements that may be suitable in some applications include sutures, tissue anchors, bone anchors, and staples. In the embodiment of Figure 9, sheet-like implant 50 is affixed to distal tendon 28 by a plurality of tendon staples 51. Sheet-like implant 50 is affixed to humerus 14 by a plurality of bone staples 100 as described with respect to the exemplary embodiment of Figure 1 and detailed throughout this disclosure. 10 [00078] In some exemplary methods, a plurality of staples may be applied using a fixation tool. After the staples are applied, the fixation tool may be withdrawn from the body of the patient. Distal tendon 28 meets humerus 14 at an insertion point 30. With reference to Figure 9, it will be appreciated that sheet-like implant 50 extends over insertion point 30. Tendon repair implant may be applied to distal tendon 28, for example, using the procedure illustrated in the 15 previous figures. In various embodiments, staples may straddle the perimeter edge of the sheet like implant (as shown in Figure 9), may be applied adjacent to the perimeter, and/or be applied to a central region of the implant. In some embodiments, the staples may be used to attach the implant to soft tissue and/or to bone. [000791 Staples or fasteners 100, as exemplified in Figure 1 and described and illustrated 20 herein can be used to attach tissue and implants to bone. In at least some embodiments, the staple is generally flexible and includes areas of relative lateral weakness on the trunks and can further include an increase in flexibility at the transition from the trunk to the non-trunk portion of the arm or the transition from the trunk to the bridge. As described above, these areas of increased flexibility provide improved staple retention as these portions allow flexing and 25 bending in response to increasing pullout forces. With this flexibility, the fasteners cannot be pounded or driven into bone or other tissue as a conventional hard staple would be driven into paper, wood, tissue or bone. Therefore, for application of the staple of the present disclosure to affixing tissue or implants to bone, the staple is generally included in a kit that also includes a staple delivery device 200 and a pilot hole forming trocar assembly 300, as schematically 30 illustrated in Figures 1 OA and 1 OB, respectively. [00080] In general, the staple delivery device 200 can include a handle assembly 201 and a barrel assembly 205. The handle assembly 201 includes a trigger 203 that is operatively coupled to mechanisms in the barrel assembly 205 to deploy a staple of the present disclosure in bone. The staple delivery device 200 can be used in conjunction with the pilot hole forming trocar 35 assembly 300 of Figure 1OB. -17- WO 2013/119321 PCT/US2012/070150 [00081] The pilot hole forming trocar assembly 300, illustrated generally in Figure 1 OB includes a trocar 302 and a position retention sleeve 304. The trocar 302 is releasably coupled to the position retention sleeve 304 and slides in keyed arrangement within the sleeve 304 when uncoupled. The trocar 302 includes a distal portion having a retractable blade 306 and a pair of 5 pilot hole forming spikes 308 extending distally from the trocar shaft. The retractable blade 306 is useful in inserting the assembly through an incision. The retractable blade 306 can be retracted in this embodiment by activating release button 315 which causes a spring (not shown) to pull the retractable blade 306 into the shaft of the trocar within the position retention sleeve 304. In this the position, the pilot hole forming spikes remain extended from the shaft. In some 10 embodiments the retractable blade 306 can be omitted if the pilot hole forming trocar assembly is to be inserted into an incision that already has a cannula extending therethrough to provide an instrument path. [00082] Referring to Figures 11 A-1 IC, details of the elements of one embodiment of a pilot hole forming trocar assembly 300 are illustrated. The pilot hole forming trocar assembly is used 15 to created pilot holes in a bone for subsequent placement of a staple or fastener, such as staple 100 of Figure 1. Further, the pilot hole forming trocar assembly includes a means for retaining instrument position with respect to the pilot holes when the trocar is removed so that a staple delivery device 200 can be inserted and the staple be in alignment with the already formed pilot holes. This prevents the time and difficulty associated with finding the pilot holes with the 20 staple, which in fact may not be possible for many practitioners. [000831 As previously stated, a pilot hole forming trocar assembly 300 can include a trocar 302 and a position retention sleeve 304. One embodiment of a position retention sleeve 304 is illustrated in Figure 1 lA. The position retention sleeve 304 includes a shaft 311 having a lumen 310 extending therethrough. The lumen 310 is sized to receive the trocar 302 when used to form 25 pilot holes. The lumen 310 is also sized to receive a staple delivery device 200 when used to position a staple in a pilot hole formed in bone. The lumen is shaped or keyed to cooperate with either of these instruments or other instruments so that relative rotational position of the trocar 302 or staple delivery device 200 is fixed when slidably positioned in the position retention sleeve. An opening or window 313 may be included near the distal end of the position retention 30 sleeve to allow viewing of devices inserted therein. [00084] Position retention members 314 extend distally from the shaft 311. As detailed in Figure 11 C, the position retention members can be included on an insert 312 that is affixed proximate the distal end of the shaft 311. Alternatively, the position retention members can be integral to the shaft 311. The position retention members are sized and designed to extend into 35 pilot holes as they are formed by the trocar 302 described below. When the trocar 302 is - 18 - WO 2013/119321 PCT/US2012/070150 removed, the position retention members 314, along with the sleeve 311 remain in position to provide a guide for the staple delivery device 200 to be inserted into proper position and position a staple 100 in the pilot holes. As depicted, the position retention members 314 can include longitudinally extending semi-cylindrical projections. In the disclosed embodiment, the pilot 5 hole forming spikes 308 of the trocar 302 slide within the partial lumens of the position retention members 314. This design can provide support for the spikes as they are pounded into bone and can also allow the position retention members to readily slide into pilot holes formed by the spikes 308. [00085] A more detailed depiction of one alternative embodiment of a trocar 302 is included 10 in Figure 11B. The trocar includes a shaft 320 having at its proximal end a knob 324 that can be used to pound or push the trocar 302 into bone. The trocar can further include a collar 322 which can be used to releasable engage the position retention sleeve 304 when the two are mated for forming pilot holes. A spring 323 can be included which causes or aids the retraction of the trocar when it is released from the position retention sleeve. 15 [00086] As previously disclosed, the distal end of the trocar 302 includes two pilot hole forming spikes 308 extending from shaft 320. A retractable blade 306 is positioned between the spikes 308. In use, the blade 306 is retracted prior to the spikes 308 being used to form pilot holes in bone. [000871 Now referring to Figure 12, the two main components of one embodiment of the 20 barrel assembly 205 are illustrated. The barrel assembly includes an outer sleeve 250 having a lumen 251 extending therethrough. The outer sleeve 250 is secured to the handle assembly 201 in fixed relationship when the staple delivery device 200 is assembled. A staple delivery assembly 252 is slidably disposed in the lumen 251 and includes a proximal end 254 extending beyond the proximal end of the sleeve 250. The proximal end 254 of the staple delivery 25 assembly 252 operatively interacts with trigger assembly 203 when the barrel 205 is mounted on the handle assembly 201. In the embodiment of Figure 12, the outer surface of the sleeve 250 is shaped so as to be rotationally keyed and sized for desired fitting within the position retention sleeve 304. The sleeve 250 includes a flat surface 257 keyed to fit within a flat surface on the interior of the position retention sleeve 304. 30 [00088] The operation of some embodiments of the staple delivery device 200 is further understood with reference to Figure 13. Figure 13 is an exploded view showing the staple delivery device 200 that may be used in conjunction with a staple 100 and the above described pilot hole forming trocar 300. The handle assembly 201 and barrel assembly 205 are shown with the barrel assembly including both the sleeve 250 and staple delivery assembly 252 included. 35 Staple delivery assembly 252 includes a fork 232, a shaft 240, and two staple setting rods 234. -19- WO 2013/119321 PCT/US2012/070150 Staple setting rods 234 include a first staple setting rod 234A and a second staple setting rod 234B. Both staple setting rods 234 are affixed to a rod coupler 236 of staple delivery assembly 252 in the embodiment of Figure 13. When the barrel 205 is in an assembled state, first staple setting rod 234A and second staple setting rod 234B can extend through two grooves defined by 5 shaft 240. Each groove is dimensioned so that a staple setting rod can be partially disposed therein while the sleeve 250 surrounds the staple setting rods 234 and shaft 240. [00089] When staple delivery device 200 is in an assembled state, staple 100 may be carried by a first stake 238A and a second stake 238B of fork 232. As previously described with respect to Figure 1, staple 100 can include a first arm 102A, a second arm 102B, and a bridge 104 10 extending from the proximal end of first arm 102A to the proximal end of second arm 102B. The distal end of the non-trunk portion of first arm 102A abuts the proximal end of a first trunk 106A. Similarly, the distal end of the non-trunk portion of second arm 102B abuts the proximal end of a second trunk 106B. [00090] Now referring to Figures 14-17, details of some exemplary embodiments and features 15 of the staple delivery assembly 252 and the mounting and delivery of a staple 100 are illustrated. Various aspects of these elements may be included in embodiments of the overall staple delivery device 200 of this disclosure. [00091] The components of a staple delivery assembly 252 are illustrated in Figure 14. First stake 238A and second stake 238B of fork 232 can be seen extending distally away from a distal 20 end of shaft 240 in figure 14. The distal direction is indicated with an arrow D. In the embodiment of Figure 14, first stake 238A includes a distal portion 244A and a proximal portion 246A. Second stake 238B includes a distal portion 244B and a proximal portion 246B. In some useful embodiments, each distal portion 244 is dimensioned to extend into a cavity defined by a staple, such as cavity 128A, 128B of staple 100 in Figure 1. When this is the case, the staple 25 may be supported by each distal portion 244 that extends into a passage defined by the staple. In this way, fork 232 may be used to carry a staple. Staple 100 is illustrated proximate the distal end of shaft 240 to show the staple features relative to the staple delivery assembly 252 prior to mounting the staple thereon. Staple setting rods 234 are illustrated as attached to rod coupler 236 and it can be seen how these rods can slidably engage the channels running longitudinally on 30 shaft 240. Spring 242 is also depicted. [00092] In Figures 15A and 15B, the staple setting rods 234, fork 232 and staple 100 are shown as initially assembled in one embodiment, prior to adding shaft 240. In particular, Figure 15B depicts fork 232 slidably disposed in channels 233. It further shows the way in which staple settings rods are disposed within cavities in the staple and the distal ends of the staple setting 35 rods 234 extend to abut a proximal surface of the staple, in this embodiment the proximal surface - 20 - WO 2013/119321 PCT/US2012/070150 is the proximal end of the trunk. In some useful methods, staple setting rods 234 are moved distally to apply pushing forces to one or more proximal surfaces of staple 100. These pushing forces may be used, for example, to urge first projection 122A and third projection 122C into orientations that lock staple 100 into a target tissue. For example, first projection 122A and third 5 projection 122C may be rotated so that these projections engage the target tissue. When this is the case, tension extending through bridge 104 of staple 100 may keep first projection 122A and third projection 122C in the rotated position. Also when this is the case, the projections may inhibit staple pullout. [000931 In Figures 16A and 16B, the initial assembly of Figure 15A is shown with the shaft 10 240 in position, along with the staple setting rods affixed to the rod coupler 236 and the spring positioned between the rod coupler 236 and the proximal end of the shaft 240. The spring 242 of staple delivery assembly 252 may be compressed as staple setting rods 234 are moved distally to urge first projection 122A and third projection 122C into orientations that lock staple 100 into a target tissue. After staple 100 has been set, spring 242 may urge staple setting rods 234 15 proximally toward a starting position. When staple delivery assembly 252 is in an assembled state, a distal end of spring 242 is seated against a proximal end of shaft 240 and a proximal end of spring 242 is seated against the distal end of rod coupler 236. Spring 242 may deflect as staple setting rods 234 are moved proximally and distally relative to shaft 140. Distal and proximal directions are indicated with arrows labeled D and P. 20 [00094] Figure 17 is a perspective view further illustrating fork 232 shown more generally in the previous figures. Fork 232 includes a first stake 238A and a second stake 238B. First stake 238A includes a distal portion 244A and a proximal portion 246A. Second stake 238B includes a distal portion 244B and a proximal portion 246B. The proximal portion 246 of each stake 238 has generally dovetail-shaped lateral cross-section. In some useful embodiments, each proximal 25 portion 246 is dimensioned to be received in a dovetail-shaped slot defined by a staple setting rod 234. When this is the case, the staple setting rod and the fork are coupled to each other with a single degree of freedom for relative movement such that the staple setting rod can slide in distal and proximal directions relative to the fork, as previously described. [00095] As depicted in the prior drawings, the manner in which a staple 100, a first staple 30 setting rod 234A and a second staple setting rod 234B engage fork 232 allows placement of the staple with active engagement and retention in the tissue or bone. Each staple setting rod 234 is disposed in sliding engagement with fork 232. A distal end of each staple setting rod 234 is disposed near a staple 100 that is carried by fork 232. [000961 Staple 100 is designed to cooperatively engage the fork and staple setting rods when 35 mounted thereon for placement in bone. As previously described, the staple 100 can include a -21- WO 2013/119321 PCT/US2012/070150 first arm 102A, a second arm 102B, and a bridge 104 extending from the proximal end of first arm 102A to the proximal end of second arm 102B. At least the distal portion of first arm 102A is a trunk that abuts a non-trunk portion of first arm 102A or the bridge 104. The same is true of second arm 102B. First trunk 106A and second trunk 106B define a first cavity 128A and a 5 second cavity 128B, respectively. [00097] Fork 132 includes a first stake 238A and a second stake 238B. A distal portion 244A of first stake 238A of fork 232 can be seen extending into first cavity 128A defined by first trunk 106A of staple 100. A distal portion 244B of second stake 238B of fork 232 extends into second cavity 128B defined by second trunk 106B of staple 100. 10 [000981 The proximal portion of each stake 238 has a generally dovetail-shaped lateral cross section. Proximal portion 246A of first stake 238A is slidingly received in a dovetail-shaped slot defined by first staple setting rod 234A. Similarly, proximal portion 246B of second stake 238B is slidingly received in a dovetail-shaped slot defined by second staple setting rod 234B. Accordingly, each staple setting rod is coupled to fork 232 with a single degree of freedom for 15 relative movement such that the staple setting rod can slide in distal and proximal directions relative to the fork. [00099] The staple setting rods 234 may be moved so that the distal end of each staple setting rod abuts a proximal surface of staple 100. Each staple setting rod may apply pushing forces to one or more proximal surfaces of staple 100. Forces applied by the staple setting rods may be 20 used to urge first projection 122A and third projection 122C into orientations that lock staple 100 into a target tissue. For example, first projection 122A and third projection 122C may be rotated so that these projections engage the target tissue. When this is the case, tension extending through bridge 104 of staple 100 may keep first projection 122A and third projection 122C in the rotated position in which the projections inhibit staple pullout. 25 [0001001 As assembled, the distal end of the staple delivery assembly 252 is enclosed by the end of the sheath 250. Initial movement of the trigger causes the stable delivery assembly to extend beyond the distal end of the sheath 150 which inserts the staple 100 into pilot holes in the bone. Continue movement of the trigger then forces the staple setting rods distally to set the staples in engagement with the bone. 30 [000101] The process of forming pilot holes and delivery staples of the present disclosure to bone is described with respect to Figures 18A- 1 8F which depict the various steps in affixing an implant 50 to bone with staples or fasteners of the present disclosure. Figure 18A schematically depicts a shoulder 22 of a patient 20 having an implant 50 positioned over a supraspinitus tendon 28. The implant is partially affixed to the tendon 28 with fasteners 51 and extends laterally to 35 and over the insertion point of the tendon to the humeral head 24. As depicted, the implant 50 is - 22 - WO 2013/119321 PCT/US2012/070150 not yet affixed to the humeral head 24. A distal portion of a pilot hole forming trocar assembly 300, in particular the position retention sleeve 304, is disposed over a desired location near the lateral edge of the implant 50 where it overlies the humeral head 24. It is noted the Figure 18A is a depiction with all overlying tissue removed from the shoulder 22 to clearly show the location 5 of the entire implant 50 on the supraspinitus tendon 28. This view is not possible during actual arthroscopic procedures in which the fasteners and instruments of the present disclosure can be used, however the depiction provides a clear understanding of the placement of an implant and the use of fasteners disclosed herein. In actual use the surgeon will have a side view from a viewing scope (not shown) of a small space created by inflating the area with fluid and clearing 10 necessary obstructions from the implant area. [0001021 Figure 18B is a schematic illustration of a cross-sectional side view of the partially affixed implant of Figure 18A showing the small portion of the implant 50 that is not yet affixed to the humeral head 24. As can be seen in the illustration, the humeral head 24 is shown in cross-section which illustrates the composite nature of bone structure. In general, bone includes 15 hard outer portion or cortical layer 375 and a porous softer inner portion or cancellous bone 376. The pilot hole forming trocar assembly 300 is positioned with the spikes 308 over a selected position on the implant 50. As previously discussed, the trocar 302 is positioned within the lumen of the position retention sleeve 304 with spikes 308 extending distally. The spikes 308 can be used to manipulate and position the implant as needed. Once in position, the spikes 308 20 can be driven into the bone. [000103] Referring to Figure 18C, the illustration of Figure 18B is re-illustrated with the pilot hole forming trocar 300 spikes pounded or otherwise driven into the humeral head 24, penetrating the cortical layer 375 into the cancellous portion 376. As illustrated, position retention members 314 also penetrate the bone with the spikes 308. In Figure 18D, it is 25 illustrated that the trocar 302 and its distal spikes 308 are now removed leaving formed pilot holes 309 with the position retention sleeve 304 remaining in position with position retention member 314 extending into pilot holes 309. The position retention member 304 lumen provides a guide to the pilot holes 309 for a staple delivery device 200. In Figure 18E, a staple 100 is shown extending into the pilot holes 309 as mounted on the distal end of a staple delivery device 30 200 that has been inserted into the lumen of position retention member 304. In this position the staple can be delivered and retained in the tissue or bone as previously described in the various embodiments disclosed herein. Figure 18F depicts a staple 100 as delivered into bone with bridge 304 holding the implant in position on the bone and arms of the staple retaining position in the in the bone, such as within the cancellous portion 376. - 23 - WO 2013/119321 PCT/US2012/070150 [000104] While exemplary embodiments of the present invention have been shown and described, modifications may be made, and it is therefore intended in the appended claims and subsequently filed claims to cover all such changes and modifications which fall within the true spirit and scope of the invention. 5 - 24 -
权利要求:
Claims (25) [1] 1. A fastener for attachment to tissue or bone comprising: a first arm having a proximal end and a distal end, a second arm having a proximal end and a distal end, and a bridge connecting the first arm and second arm, wherein each of the first and second arms include a trunk portion extending over at least a portion of the length thereof, 5 each trunk having a lateral extent larger than a lateral extent of the bridge or non-trunk arm portion adjacent thereto such that the staple includes a first change in lateral stiffness disposed proximate the bridge or non-trunk arm portion abutment with the first trunk and a second change in lateral stiffness disposed proximate the bridge or non-trunk arm portion abutment with the second trunk; 10 each trunk including a first projection and a second projection, the first projection including a first proximal surface extending away from the trunk in a first direction, the first direction being such that the first proximal surface will engage the tissue or bone when the trunk is inserted therein so that a first moment is applied to the trunk in response to a pullout force on the bridge, the second projection including a second proximal surface extending away from the 15 trunk in a second direction, the second direction being such that the second proximal surface will engage the tissue or bone when the trunk is inserted therein so that a second moment is applied to the trunk in response to a pullout force on the bridge, each of the trunks including a localized area of weakness proximate the second projection thereon. [2] 2. The fastener of claim 1, wherein the change in lateral stiffness and the localized 20 area of weakness allow flexing of each arm portion in response to the first and second moment, respectively. [3] 3. The fastener of claim 1, wherein the first direction extends proximally and laterally away from each trunk, the second direction extends proximally and laterally away from 25 the each trunk and a lateral component of the second direction is generally opposite a lateral component of the first direction. [4] 4. The fastener of claim 2, wherein the direction of the first moment is generally opposite the direction of the second moment on each arm. 30 [5] 5. The fastener of claim 1, wherein each of the first trunk and the second trunk define a cavity, each cavity being spaced laterally from the respective non-trunk portion or - 25 - WO 2013/119321 PCT/US2012/070150 bridge adjacent thereto, and each cavity defined by the first and the second trunk is sized to receive a first stake and a second stake, respectively, of a fastener delivery device. [6] 6. The fastener of claim 5, wherein each cavity defined by the first and the second 5 trunk extends from a proximal end to a distal end of the trunk. [7] 7. The fastener of claim 1, wherein the first arm, the second arm and the bridge are integrally formed of a polymeric material. 10 [8] 8. The fastener of claim 7, wherein the polymeric material comprises a polyether ether ketone (PEEK) material. [9] 9. The fastener of claim 1, wherein the lateral cross extent of each trunk in at least one direction is at least about three times the lateral extent of at least a portion of the bridge or 15 non-trunk portion of the arm. [10] 10. The fastener of claim 9, wherein the lateral extent of at least a portion of the bridge or non-trunk portion of the arm is about 0.3 mm to about 3.0 mm. 20 [11] 11. A staple for insertion and retention in tissue or bone comprising: a bridge portion having arms extending from proximate each end thereof, at least a portion of each arm including tissue retention members, each tissue retention member having at least two barbed projections extending laterally therefrom with each tissue retention member having a cross sectional area of reduced strength proximate each projection relative to other 25 portions of the tissue retention member such that a portion of the tissue retention member flexes laterally proximate each projection in response to a pullout force applied to the bridge. [12] 12. The staple of claim 11, wherein one area of reduced strength includes the transition from tissue retention member to arm or bridge of the staple. 30 [13] 13. The staple of claim 12, wherein a second area of reduced strength includes a slit in the cross section of the tissue retention member adjacent at least one of the projections therefrom. - 26 - WO 2013/119321 PCT/US2012/070150 [14] 14. The staple of claim 11, wherein the projections on each arm are positioned to create flexing of the tissue retention member in generally opposite directions. [15] 15. The staple of claim 11, wherein each of the tissue retention members define a 5 cavity, each cavity being spaced laterally from the respective arm or bridge portion adjacent thereto, with each cavity sized to receive a first stake and a second stake, respectively, of a staple delivery device. [16] 16. The staple of claim 15, wherein each cavity extends from the proximal end to the 10 distal end of the tissue retention member. [17] 17. The staple of claim 11, wherein the tissue retention members and the bridge are integrally formed of a polymeric material. 15 [18] 18. The staple of claim 17, wherein the polymeric material comprises a polyether ether ketone (PEEK) material. [19] 19. The staple of claim 11, wherein the lateral extent of at least a portion each tissue retention member is at least about three times the lateral extent of at least of portion of the bridge 20 or arm portion adjacent thereto. [20] 20. The staple of claim 19, wherein the lateral extent of the bridge or arm portion is about 0.3 mm. to about 3.0 mm. 25 [21] 21. A fastener delivery tool comprising: a barrel assembly having an outer sheath with a staple delivery assembly disposed therein, the staple delivery assembly including a shaft having a pair of stakes extending from a distal end thereof, the stakes sized and shaped to retain a fastener thereon; the staple delivery assembly further including a pair of staple setting rods extending 30 along the length of the shaft having distal portions proximate the stakes to engage a proximal surface on the fastener wherein distal longitudinal movement of the staple setting rods relative to the stakes aids in delivery of the fastener; and, a handle assembly fixed to the outer sheath of the barrel in operative relationship with the staple delivery assembly. 35 -27- WO 2013/119321 PCT/US2012/070150 [22] 22. The fastener delivery tool of claim 21, wherein the staple delivery assembly is longitudinally extendable from a first position enclosed within the sheath to a second position wherein at least a portion of the staple delivery assembly extends distally from the sheath. [23] 23. The fastener delivery tool of claim 21, wherein the staple delivery assembly 5 includes a proximal shaft portion having a proximal portion of the staple setting rods fixed thereto and a distal portion with a spring therebetween to allow relative longitudinal movement between the stakes and the staple setting rods in response to increased force on the proximal end of the staple delivery assembly. 10 [24] 24. The fastener delivery tool of claim 21, wherein at least a portion of the stakes have a cross sectional shape that sliding engages a channel of like cross sectional shape on a distal portion of the staple setting rods to restrict relative motion of the stakes and staple setting rods in the longitudinal direction. 15 [25] 25. The fastener delivery tool of claim 21, wherein the stakes are formed on a fork member fixed to a distal end of the shaft of the staple delivery assembly. -28-
类似技术:
公开号 | 公开日 | 专利标题 US11020111B2|2021-06-01|Fasteners and fastener delivery devices for affixing sheet-like materials to bone or tissue US10039544B2|2018-08-07|Fasteners and fastener delivery devices for affixing sheet-like materials to bone or tissue US10912640B2|2021-02-09|Apparatus and method for forming pilot holes in bone and delivering fasteners therein for retaining an implant US9955968B2|2018-05-01|Fasteners and fastener delivery devices for affixing sheet-like materials to bone or tissue US9005224B2|2015-04-14|Methods and apparatus for delivering and positioning sheet-like materials AU2010256414B8|2015-05-28|Methods and apparatus for deploying sheet-like materials
同族专利:
公开号 | 公开日 AU2012369140B2|2016-11-10| US11020111B2|2021-06-01| EP3363371A2|2018-08-22| US20130240598A1|2013-09-19| US9566063B2|2017-02-14| US9370356B2|2016-06-21| EP3363371A3|2018-09-12| WO2013119321A1|2013-08-15| US20130153627A1|2013-06-20| EP2793712B1|2018-03-28| CA2859548A1|2013-08-15| US20160262747A1|2016-09-15| EP2793712A1|2014-10-29|
引用文献:
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法律状态:
2017-03-09| FGA| Letters patent sealed or granted (standard patent)|
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申请号 | 申请日 | 专利标题 US201161577626P| true| 2011-12-19|2011-12-19|| US61/577,626||2011-12-19|| PCT/US2012/070150|WO2013119321A1|2011-12-19|2012-12-17|Fasteners for affixing sheet -like materials to bone or tissue| 相关专利
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